Source
MAJOR SPOILERS AHEAD
The following information is courtesy of TFLAMB:
Opens with moon landing, Armstrong saying "Roger Control-7" likely a Sector 7 reference. (pages 3-5)
A character named Wheeljack is in the movie. Look and alt mode unknown but "Einstein" seems likely. (page 8)
Carly and Sam are already living together in Washington, DC along with the Transformer Brains. I can't tell what he is other than he has spiky gray "hair." (pages 9-10, 29)
Sentinel Prime shoots Ironhide in the face with at least one of the Twins watching. (pages 46-47)
Soundwave is the silver Mercedes-Benz [SLS AMG -ED], he is in that form when he captures Carly explaining why she was spotted in the vehicle on the Chicago sets. (page 60)
Dylan (Patrick Dempsey), whose father helped hide true nature of moon missions, is working for the Decepticons and seems to be ordering some of them around. (page 60)
Carly is captured so Dylan can force Sam to spy on the Autobots. (page 61)
Sentinel Prime, announcing himself the "true leader of the Autobots", demands the world's natural resources so can rebuild Cybertron and wants the "rebels" (aka Optimus and company) exiled from Earth. (page 62)
Sentinel Prime had joined forces with Megatron so "that our planet may survive." and seems plans to use his space bridge to transport Earth to Cybertron. (page 72)
Dylan: "How many rocks out there in the universe offer a six billion strong slave labor force?" (page 72)
The giant worm thing is called "Driller" (page 75)