I reckon if they're gonna do Transformers Generations, then set it
after the events of Generation 2... so basically in the same spirit as ReGeneration One --- it's been 20 years since G2 ended, and the G1 Transformers now look like Classicsverse... new story, new show, new comics -- boom. If they're clever they can also start seeding things that will connect with Beast Wars (helping to 'bridge' the continuity gap between G2 and BW). Like maybe have an episode where Classicsverse Megatron finds the Voyager II and embeds his message on the Sounds of Earth disc (after all in BW we only really see the reflection of his head, which pretty much looks like Classics Megs

). Have an episode where Deluxe sized Optimus Prime, Bumblebee, Prowl, Trailcutter, Hound and Warpath volunteer to become Perceptor's first test subject to have their bodies reformatted to a smaller but more fuel-efficient form (i.e. their Legends Class toys)... a process he calls the "Maximal Upgrade." This technology could then be stolen by the Predacons, who then apply it to Megatron and Starscream. The technology still has its drawbacks, so maybe after an episode or so they all return to their regular Deluxe and Voyager sized bodies -- but at least the Legends toys still get a plug, and the story lays seeds for the future Maximal and Predacon upgrades that we see in Beast Wars (and further explains why the Maximals and Predacons are so much smaller than Autobots and Decepticons). Instead of humans and M.E.C.H., they could have a sub story about the Matrix-purified-Swarm evolving into the Vok... and how/why they decide to go back in time and do all that funky stuff to prehistoric Earth.