Does Jazz have a nemesis?

[Paulbot]

Well there's not really anyone he's "always" fighting.

I would say Soundwave, because of their sound powers, their similar right-hand-man positions to their leaders, the saboteur vs the spy, and drastic differences between their relaxed/repressed personalities. Blaster kind of took the role of Soundwave's nemesis though.

So I'd go with Skywarp because their fight in the original opening credits (that was reused in the toy ads) is something there from the beginning, and the toy's colours contrast each other well.

[Sinnertwin]

Nothing immediately comes to mind from the cartoon, unlike Sky Lynx & the Predacons for example.
Bio wise, i suppose Needlenose could be somewhat considered based on his motto "Get hip or get hit" & his accompanying blurb: The coolest Decepticon ever to crush an Autobot, fascinated by Earthly fads etc
I imagine the meeting of the two could be very interesting

[fatbot]

Based purely on the name, I'd say Motörhead.

[1orion2many]

Based purely on the name, I'd say Motörhead.

I'd go with this

[GoktimusPrime]

Megatron's hands.

As a kid I always thought of Jazz's nemesis as Starscream, simply because I perceived them as the "Number Twos" of their respective sides.