You can, but I wouldn't recommend it.
You should only run one anti-virus on your system as they dont play nice with each other.
If your system has been breached then running scans, system restores and such from safe mode is often your best bet as safe mode limits file and registry access (less chance of the virus spreading).
I would say get SpyBotSD and run it a few times to check the registry for nastys.
That program coupled with your anti-virus and windows user account control (which is on by default) should protect you.