I haven't had it crash in the last few days, but am getting bugged by HD loading pausing the game from time to time.

A "glitch" of sorts I wanted to mention as well is an audio one - if someone is talking to your character in the campaign, make sure you are facing them, because if you turn away, even slightly, there's silence (on the PS3 at least). On some occasions I'm off looking around for stuff and then suddenly realise that someone was talking, but missed most of it.
I know there isn't really anything required in what other characters tell you, but it makes the story more interesting to hear tid-bits of what is going on around you. (like the Audiologs - those were a GREAT way to tell a lot of the "story" in this Universe/game, without the game being bogged down by narration or speeches by other characters... an excellent gimmick making it them hidden trophy/achievements that don't get in the way of playing out the game itself)