Prime obvioiusly, then whatever comes after that, and then the toyline for the fourth movie (Hasbro have said they'd like to keep it going, Bay or not).
I'd like to see them keep doing what they started to do towards the back end of Universe 2.0 - updates of non G1 characters. Even if they're going to stick to G1 they've still got a lot of characters needing updating (bear in mind each iterations of Classics has about 10 - 15 new molds that they then repaint/give a new head to) - they'll be going for a while yet. I'd like to see a proper Classics styled Springer and Arcee. I'd also like to see more of the Rebirth Targetmasters to go with Cyclonus - I've got Scourge and Energon Slugslinger with appropriated Nightsticks from various repaints of Cyclonus on my Classics shelf. I'd like to add to this.
Also I'd be really keen for new WFC stuff (or if not that directly then new cybertron mode figures with movie esque stylings). The WFC stuff and the 2007 Protoform figures have been some of my favourites in recent times.