Do you think there's a big difference between toys that are kept MIB (mint in box, so it means you have opened and played with it, but kept the toy and box in good condition) vs MISB/MOSC (mint in sealed box/mint on sealed card) in terms of value?

Like have there been any examples of toys that's values have dropped heaps because of the MIB/MISB difference?

I'm a MIB collector myself and though I don't see myself selling my TF anytime soon, I actually like to keep the boxes though it's space-costing