I've nothing against Jason Statham being in a fourth move, but for some reason the scene of Spike vs Scrapper from the IDW comic comes to mind. I'd imagine a movie staring him would have less robot vs robot action which I think fans wouldn't like.
If it's not a total reboot then at least one familiar character should come back. Leo from ROTF would probably be a cheap hire to get back. Epps too most likely. Neither actor has an existent movie careers and it could be an interesting pair up!